Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum.

  title={Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum.},
  author={Delphine Meffre and Ghjuvan'ghjacumu Shackleford and Mehdi Hichor and Victor Gorgievski and Eleni Th Tzavara and Amalia Trousson and Abdel M Ghoumari and Cyrille Deboux and Brahim Nait Oumesmar and Philippe Li{\`e}re and Michael Schumacher and Etienne Emile Baulieu and Fr{\'e}d{\'e}ric Charbonnier and Julien Grenier and Charbel Massaad},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 24},
The identification of new pathways governing myelination provides innovative avenues for remyelination. Liver X receptors (LXRs) α and β are nuclear receptors activated by oxysterols that originated from the oxidation of cholesterol. They are crucial for cholesterol homeostasis, a major lipid constituent of myelin sheaths that are formed by oligodendrocytes. However, the role of LXRs in myelin generation and maintenance is poorly understood. Here, we show that LXRs are involved in myelination… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 16 extracted citations

LXR Regulation of Brain Cholesterol: From Development to Disease.

Trends in endocrinology and metabolism: TEM • 2016
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…