Liver X receptor up-regulates α-tocopherol transfer protein expression and α-tocopherol status.

@article{Koh2013LiverXR,
  title={Liver X receptor up-regulates α-tocopherol transfer protein expression and α-tocopherol status.},
  author={Maki Koh and Kimitaka Takitani and Hiroshi Miyazaki and Shigeo Yamaoka and Hiroshi Tamai},
  journal={The Journal of nutritional biochemistry},
  year={2013},
  volume={24 12},
  pages={2158-67}
}
Fat-soluble vitamin E (α-tocopherol) has antioxidant activity. α-Tocopherol transfer protein (α-TTP), a hepatic cytosolic protein, selectively binds α-tocopherol and has an important role regulating circulatory α-tocopherol levels. However, only a few studies have shown the transcriptional regulation of the α-TTP gene. Here, we demonstrate that liver X receptor (LXR) regulates α-TTP expression through direct interaction with the α-TTP gene promoter, and it modulates circulating α-tocopherol… CONTINUE READING

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Fat - soluble vitamin E ( α-tocopherol ) has antioxidant activity .
Fat - soluble vitamin E ( α-tocopherol ) has antioxidant activity .
Fat - soluble vitamin E ( α-tocopherol ) has antioxidant activity .
Fat - soluble vitamin E ( α-tocopherol ) has antioxidant activity .
Fat - soluble vitamin E ( α-tocopherol ) has antioxidant activity .
LXR belongs to the nuclear receptor superfamily , acts as a ligand - dependent transcription factor for oxysterols and plays an important role in cholesterol metabolism and lipogenesis .
Fat - soluble vitamin E ( α-tocopherol ) has antioxidant activity .
Fat - soluble vitamin E ( α-tocopherol ) has antioxidant activity .
LXR belongs to the nuclear receptor superfamily , acts as a ligand - dependent transcription factor for oxysterols and plays an important role in cholesterol metabolism and lipogenesis .
LXR belongs to the nuclear receptor superfamily , acts as a ligand - dependent transcription factor for oxysterols and plays an important role in cholesterol metabolism and lipogenesis .
LXR belongs to the nuclear receptor superfamily , acts as a ligand - dependent transcription factor for oxysterols and plays an important role in cholesterol metabolism and lipogenesis .
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