Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages.

  title={Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages.},
  author={Antonio Castrillo and Sean B. Joseph and Chaitra Marathe and David J Mangelsdorf and Peter Tontonoz},
  journal={The Journal of biological chemistry},
  volume={278 12},
Matrix metalloproteinases (MMPs) are zinc endopeptidases that degrade extracellular matrix (ECM) components during normal and pathogenic tissue remodeling. Inappropriate expression of these enzymes contributes to the development of vascular pathology, including atherosclerosis. MMP-9 is expressed in its active form in atherosclerotic lesions and is believed to play an important role in vascular remodeling, smooth muscle cell migration, and plaque instability. We demonstrate here that the liver… CONTINUE READING
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