Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells.

@article{Norata2005LiverXR,
  title={Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells.},
  author={Giuseppe D. Norata and Manuele Ongari and Patrizia Uboldi and Fabio Pellegatta and Alberico L. Catapano},
  journal={International journal of molecular medicine},
  year={2005},
  volume={16 4},
  pages={717-22}
}
The cooperation of liver X receptors (LXRs) alpha and beta, and retinoic X receptor (RXR) modulate the expression of several genes involved in lipid metabolism in hepatocyte and macrophages. Using cDNA microarray technology, we have shown previously that several of these genes are also expressed in endothelial cells. In the present study, we investigated whether the activation of LXR and RXR affects the expression of genes involved in lipid metabolism in human endothelial cells. Relative… CONTINUE READING