Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype.

@article{Wang2008LiverXR,
  title={Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype.},
  author={Haibo Wang and Yuan Zhang and Einav Yehuda-Shnaidman and Alexander V Medvedev and Naresh Kumar and Kiefer W. Daniel and Jacques Robidoux and M. Czech and David J Mangelsdorf and Sheila Collins},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 7},
  pages={2187-200}
}
The adipocyte integrates crucial information about metabolic needs in order to balance energy intake, storage, and expenditure. Whereas white adipose tissue stores energy, brown adipose tissue is a major site of energy dissipation through adaptive thermogenesis mediated by uncoupling protein 1 (UCP1) in mammals. In both white and brown adipose tissue, nuclear receptors and their coregulators, such as peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgamma coactivator 1alpha… CONTINUE READING
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