Liver X receptor agonists ameliorate TNFα-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression

@article{FernndezVeledo2006LiverXR,
  title={Liver X receptor agonists ameliorate TNFα-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression},
  author={Sonia Fern{\'a}ndez-Veledo and Iria Nieto-V{\'a}zquez and Christina M Rondinone and Margarita Lorenzo},
  journal={Diabetologia},
  year={2006},
  volume={49},
  pages={3038-3048}
}
The nuclear receptors, including nuclear receptor subfamily 1, group H, member 3 (NR1HR, also known as liver X receptor [LXR]), are sensors of cholesterol metabolism and lipid biosynthesis that have recently been proposed as insulin sensitisers. TNFα has been described as a link between obesity and the development of insulin resistance, an important contributor to the pathogenesis of type 2 diabetes. Therefore, we decided to investigate the ability of NR1HR agonists to ameliorate TNFα-induced… CONTINUE READING

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