Liver X receptor activation restores memory in aged AD mice without reducing amyloid.

Abstract

Alterations in cerebral cholesterol metabolism are thought to play a role in the progression of Alzheimer's disease (AD). Liver X receptors (LXRs) are key regulators of cholesterol metabolism. The synthetic LXR activator, T0901317 has been reported to improve memory functions in animal models for AD and to reduce amyloid-β (Aβ) deposition in the brain. Here… (More)
DOI: 10.1016/j.neurobiolaging.2009.07.005

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