Liver X receptor activation induces the uptake of cholesteryl esters from high density lipoproteins in primary human macrophages.

Abstract

OBJECTIVE Liver X receptors (LXRs) are oxysterol-activated nuclear receptors regulating reverse cholesterol transport, in part by modulating cholesterol efflux from macrophages to apoAI and HDL via the ABCA1 and ABCG1/ABCG4 pathways. Moreover, LXR activation increases intracellular cholesterol trafficking via the induction of NPC1 and NPC2 expression… (More)
DOI: 10.1161/ATVBAHA.108.175042

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