Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation.

@article{Cui2011LiverXR,
  title={Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation.},
  author={Guoliang Cui and Xia Qin and Lili Wu and Yuebo Zhang and Xiaoyan Sheng and Qiwen Yu and Hongguang Sheng and Beili Xi and Jingwu Z. Zhang and Ying C. Q. Zang},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 2},
  pages={658-70}
}
Th17 cells are a subset of CD4+ T cells with an important role in clearing certain bacterial and fungal pathogens. However, they have also been implicated in autoimmune diseases such as multiple sclerosis. Exposure of naive CD4+ T cells to IL-6 and TGF-β leads to Th17 cell differentiation through a process in which many proteins have been implicated. We report here that ectopic expression of liver X receptor (LXR) inhibits Th17 polarization of mouse CD4+ T cells, while LXR deficiency promotes… CONTINUE READING

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