Liver X Receptor ( LXR )-Regulation in LXR-Deficient Mice : Implications for Therapeutic Targeting

@inproceedings{Quinet2006LiverXR,
  title={Liver X Receptor ( LXR )-Regulation in LXR-Deficient Mice : Implications for Therapeutic Targeting},
  author={Elaine M. Quinet and Dawn A. Savio and Anita R. Halpern and Liang Chen and Gertrude U. Schuster and Jan-{\AA}ke Gustafsson and Mike D. Basso and P. Azhahia Nambi},
  year={2006}
}
The nuclear receptors liver X receptor (LXR) LXR and LXR are differentially expressed ligand-activated transcription factors that induce genes controlling cholesterol homeostasis and lipogenesis. Synthetic ligands for both receptor subtypes activate ATP binding cassette transporter A1 (ABCA1)-mediated cholesterol metabolism, increase reverse cholesterol transport, and provide atheroprotection in mice. However, these ligands may also increase hepatic triglyceride (TG) synthesis via a sterol… CONTINUE READING

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