Liver Transplantation Using Donation After Cardiac Death Donors: Long‐Term Follow‐Up from a Single Center
@article{deVera2009LiverTU, title={Liver Transplantation Using Donation After Cardiac Death Donors: Long‐Term Follow‐Up from a Single Center}, author={Michael E. de Vera and Roberto Carlos Lopez-Solis and Igor Dvorchik and Sofia Campos and William Morris and Anthony J. Demetris and Paulo Fontes and James Wallis Marsh}, journal={American Journal of Transplantation}, year={2009}, volume={9} }
There is a lack of universally accepted clinical parameters to guide the utilization of donation after cardiac death (DCD) donor livers and it is unclear as to which patients would benefit most from these organs. We reviewed our experience in 141 patients who underwent liver transplantation using DCD allografts from 1993 to 2007. Patient outcomes were analyzed in comparison to a matched cohort of 282 patients who received livers from donation after brain death (DBD) donors. Patient survival was…
241 Citations
Impact of donor age in liver transplantation from donation after circulatory death donors: A decade of experience at Cleveland Clinic
- MedicineLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
- 2015
The use of liver grafts from donation after circulatory death (DCD) donors remains controversial, particularly with donors of advanced age. This retrospective study investigated the impact of donor…
Impact of donor age in donation after circulatory death liver transplantation: Is the cutoff “60” still of relevance?
- MedicineLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
- 2018
Older DCD donors can be successfully used for liver transplantation with good longterm outcomes when further risk factors are limited, and donor body mass index above a threshold of 25 kg/m2 significantly impacted on graft and patient survival at any donor age, whereas donor warm ischemia times were not predictive for graft loss.
Liver transplantation with donation after cardiac death donors: a comprehensive update.
- MedicineThe Journal of surgical research
- 2012
Livers From Pediatric Donation After Circulatory Death Donors Represent a Viable and Underutilized Source of Allograft
- MedicineLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
- 2020
It is found that pediatric DCD allografts are recovered at a significantly lower rate than from 18‐to‐40‐year‐old donors, but once recovered, these organs are transplanted at a similar rate to those from the 18-to-40-year-old donor cohort.
Liver transplantation from donation after cardiac death donors: initial Belgian experience 2003–2007
- MedicineTransplant international : official journal of the European Society for Organ Transplantation
- 2010
Results were inferior to those obtained with donation after brain death LT in this series, and prognostic criteria have to be developed to improve results of DCD‐LT.
Donation after Cardiac Death Liver Transplantation: Predictors of Outcome
- MedicineAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
- 2010
Findings are useful for transplant surgeons creating DCD liver acceptance protocols and should be considered for consideration for future transplant protocols.
Liver Transplantation Using Grafts From Donors After Circulatory Death: A Propensity Score–Matched Study From a Single Center
- MedicineAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
- 2016
With appropriate recipient selection, the use of DCDs, including those deemed marginal, can be safe and can produce outcomes comparable to those seen using DBD grafts in similar recipients.
The price of donation after cardiac death in liver transplantation: a prospective cost‐effectiveness study
- Medicine, Political ScienceTransplant international : official journal of the European Society for Organ Transplantation
- 2013
Reimbursement should be differentiated to better accommodate DCD transplantations, as DCD livers have more and more severe complications, more reinterventions and consequently higher costs than DBD livers.
Comparison of longterm outcomes and quality of life in recipients of donation after cardiac death liver grafts with a propensity‐matched cohort
- MedicineLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
- 2017
Prevention of IC in DCD LT yields excellent graft and patient survival with virtually no difference compared with DBD LT, and similar longterm survival and QOL scores can be achieved between DCDLT and DBDLT.
Selected liver grafts from donation after circulatory death can be safely used for retransplantation – a multicenter retrospective study
- MedicineTransplant international : official journal of the European Society for Organ Transplantation
- 2020
ReLT with DCD grafts does not result in inferior patient and graft survival compared with DBD grafts in selected patients, and DCD liver grafts should not routinely be declined for patients awaiting reLT.
References
SHOWING 1-10 OF 30 REFERENCES
Donation After Cardiac Death as a Strategy to Increase Deceased Donor Liver Availability
- Medicine, Political ScienceAnnals of surgery
- 2006
The annual number of DCD livers used for transplant has increased rapidly and are associated with a significantly increased risk of graft failure unrelated to modifiable donor or recipient factors, but Appropriate recipients for DCd livers have not been fully characterized.
Donation After Cardiac Death: The University of Wisconsin Experience With Liver Transplantation
- MedicineAnnals of surgery
- 2005
Despite similar rates of primary nonfunction,LTx after controlled DCD resulted in worse patient and graft survival compared with LTx after DBD and increased incidence of biliary complications and hepatic artery stenosis; however, overall results of LTX after controlledDCD are encouraging; and with careful donor and recipient selection, LTx before DCD may successfully increase the donor liver pool.
Factors Affecting Graft Survival After Liver Transplantation from Donation After Cardiac Death Donors
- MedicineTransplantation
- 2006
D livers from young donors with short DWIT and CIT should be given greater consideration in order to expand the number of available donor organs, as well as donor and recipient characteristics that are associated with poor allograft outcomes.
Risk Factors for Graft Survival After Liver Transplantation from Donation After Cardiac Death Donors: An Analysis of OPTN/UNOS Data
- MedicineAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
- 2006
Liver allografts from DCD donors may be used to increase the cadaveric donor pool, with favorable graft survival rates achieved when low‐risk grafts are transplanted in a low‐ risk setting.
Ischemic cholangiopathy following liver transplantation from donation after cardiac death donors
- MedicineLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
- 2008
There is a higher incidence of ischemic cholangiopathy in recipients receiving DCD donor livers; however, patient and graft outcomes with DCD donors remain comparable to those with DBD donors.
Survival Following Liver Transplantation From Non-Heart-Beating Donors
- MedicineAnnals of surgery
- 2004
Graft and patient survival is inferior among recipients of NHBD livers; however, judicious use is warranted, including minimization of cold ischemia and use in stable recipients.
Using livers from donation after cardiac death donors—A proposal to protect the true Achilles heel
- MedicineLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
- 2007
While patient survival and graft survival have improved in more recent eras, the impact of DCD on liver transplantation, as assessed from the Scientific Registry of Transplant Recipients (SRTR) database, shows that DCD graft survival was significantly lower than that of donation after brain death (DBD) grafts.
CONTROLLED NON-HEART-BEATING DONOR LIVER TRANSPLANTATION: A Successful Single Center Experience, with Topic Update
- MedicineTransplantation
- 2000
A successful experience of controlled non-heart-beating donor (NHBD) liver transplantation is described and cautious liberalization of criteria for accepting livers from NHBDs with confounding risk factors is justified.
Single-Center Experience With Liver Transplantation From Controlled Non-Heartbeating Donors: A Viable Source of Grafts
- MedicineAnnals of surgery
- 2005
Early results suggest that controlled NHBDs are a significant new source of grafts, but careful donor selection and short cold ischemia are mandatory.
Use of older controlled non-heart-beating donors for liver transplantation
- MedicineTransplantation
- 2003
In the preliminary experience, recipients of liver grafts from older CNHBDs had an outcome equivalent to that of younger CNH BDs, which warrants consideration to expand the donor pool.