Liver-Specific Disruption of the Murine Glucagon Receptor Produces α-Cell Hyperplasia

  title={Liver-Specific Disruption of the Murine Glucagon Receptor Produces α-Cell Hyperplasia},
  author={Christine Longuet and Ana M. Robledo and Erika Danielle Dean and Chunhua Dai and Safina Ali and Ian McGuinness and Vincent de Chavez and Patricia Myriam Vuguin and Maureen J. Charron and Alvin C Powers and Daniel J Drucker},
Glucagon is a critical regulator of glucose homeostasis; however, mechanisms regulating glucagon action and α-cell function and number are incompletely understood. To elucidate the role of the hepatic glucagon receptor (Gcgr) in glucagon action, we generated mice with hepatocyte-specific deletion of the glucagon receptor. Gcgr(Hep)(-/-) mice exhibited reductions in fasting blood glucose and improvements in insulin sensitivity and glucose tolerance compared with wild-type controls, similar in… CONTINUE READING
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