Liver Regeneration

@inproceedings{Michalopoulos1997LiverR,
  title={Liver Regeneration},
  author={George K. Michalopoulos and Marie Defrances},
  booktitle={Journal of Cellular Physiology},
  year={1997}
}
Liver regeneration after the loss of hepatic tissue is a fundamental parameter of liver response to injury. Recognized as a phenomenon from mythological times, it is now defined as an orchestrated response induced by specific external stimuli and involving sequential changes in gene expression, growth factor production, and morphologic structure. Many growth factors and cytokines, most notably hepatocyte growth factor, epidermal growth factor, transforming growth factor-α, interleukin-6, tumor… 
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657 Citations
Highly Influential Citations
35
Background Citations
275
Methods Citations
18
Results Citations
6

657 Citations

Liver Regeneration and Immunity: A Tale to Tell

The aim of this review is to add new findings that integrate the regenerative pathway to the current knowledge, to allow a more detailed characterisation of the molecular mechanisms that are crucial in the interplay between proliferation and inflammation.

Liver regeneration.

Epithelial Plasticity during Liver Injury and Regeneration.

Redox experimental medicine and liver regeneration

Modulation of redox-dependent molecular pathways to enhance liver regeneration is even more intriguing, and preliminary studies focused on the identification of these targets will pave the way for viable therapies to be tested in clinical trials.

The balancing act of the liver: tissue regeneration versus fibrosis

The cellular and molecular switches that balance hepatic regeneration and fibrosis are explored, with a focus on uncovering avenues of disease modeling and therapeutic intervention.

Liver Regeneration: Different Sub-Populations of Parenchymal Cells at Play Choreographed by an Injury-Specific Microenvironment

The molecular mechanisms supporting liver regeneration and parenchymal reconstitution are reviewed to determine potential targets that would be amenable for therapeutic manipulation to enhance liver regeneration.

A model of liver regeneration.

Liver regeneration: biological and pathological mechanisms and implications

The regenerative mechanisms employed by hepatic cells after liver injury as well as the experimental models used to investigate these mechanisms are described and the clinical implications are discussed.

EMERGING ROLES OF PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA IN CHRONIC LIVER INJURY: POTENTIAL THERAPEUTIC TARGET IN HEPATIC FIBROSIS

A distinct pro-fibrotic role of PDGFRα in HSCs during chronic liver injury in both mice and human primary cells is supported and provides an important pre-clinical foundation for the future testing of therapeutic PDG FRα inhibition in hepatic fibrosis.

Hallmarks of postoperative liver regeneration: An updated insight on the regulatory mechanisms

Eight hallmarks, including hepatocyte proliferation, contribution of hepatic progenitor cells, inducing angiogenesis, reprogramming of the extracellular matrix, apoptosis and termination of proliferation, inflammation, immune and metabolic regulation, are set as organizing characteristics of postoperative liver regeneration and future directions of refining treatment targets.
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References

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The numerous cytokine- and growth-factor-mediated pathways that are involved in regulating liver regeneration are being successfully dissected using molecular and genetic approaches.

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The present overview summarizes important knowledge having accumulated during the last years about liver regeneration, which has in part been defined by use of animal models with target gene deletions (gene knockouts).

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It is reported that the hepatocyte proliferative response to partial liver resection is severely inhibited in transgenic mice with targeted disruption of the iNOS gene, suggesting that during successful tissue regeneration, injury-related cytokines induce factors, such as iN OS and its product, NO, that protect surviving cells from cytokine-mediated death.
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