Liver Kupffer cells rapidly remove red blood cell-derived vesicles from the circulation by scavenger receptors.

@article{Willekens2005LiverKC,
  title={Liver Kupffer cells rapidly remove red blood cell-derived vesicles from the circulation by scavenger receptors.},
  author={Frans L A Willekens and Jan M Werre and Johan Kar Kruijt and Bregt Roerdinkholder-Stoelwinder and Yvonne A M Groenen-D{\"o}pp and Annegeet G van den Bos and Giel J. G. C. M. Bosman and Theo J. C. van Berkel},
  journal={Blood},
  year={2005},
  volume={105 5},
  pages={2141-5}
}
Previous studies have shown that during the lifespan of red blood cells (RBCs) 20% of hemoglobin is lost by shedding of hemoglobin-containing vesicles. However, the fate of these vesicles is unknown. To study this fate we used a rat model, after having established that rat RBCs lose hemoglobin in the same way as human RBCs, and that RBC-derived vesicles are preferentially labeled by Na2(51) CrO4. Such labeled vesicles were injected into recipient rats. Within 5 minutes, 80% of the radioactivity… CONTINUE READING