Liver Gene Expression Profiles Correlate with Virus Infection and Response to Interferon Therapy in Chronic Hepatitis B Patients

  title={Liver Gene Expression Profiles Correlate with Virus Infection and Response to Interferon Therapy in Chronic Hepatitis B Patients},
  author={Hui-Lin Wu and Tzu-Hung Hsiao and Pei-Jer Chen and S H Wong and Jia-Horng Kao and D. -S. Chen and Jo-Yang Lu and Tzu-Pin Lu and Yidong Chen and Eric Y. Chuang and Hui-Chu Tu and Chun-Jen Liu},
  booktitle={Scientific reports},
The natural course of chronic hepatitis B (CHB) infection and treatment response are determined mainly by the genomic characteristics of the individual. We investigated liver gene expression profiles to reveal the molecular basis associated with chronic hepatitis B and IFN-alpha (IFNα) treatment response in CHB patients. Expression profiles were compared between seven paired liver biopsy samples taken before and 6 months after successful IFNα treatment or between pretreatment biopsy samples of… CONTINUE READING
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