Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis

@inproceedings{Recknagel2012LiverDA,
  title={Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis},
  author={Peter Recknagel and Falk A. Gonnert and Martin Westermann and Sandro Lambeck and Amelie Lupp and Alain Rudiger and Alex Dyson and Jane E. Carr{\'e} and Andreas Kortgen and Christoph Krafft and J{\"u}rgen Popp and Christoph Sponholz and Valentin Fuhrmann and I. Hilger and Ralf Alexander Claus and Niels Riedemann and Reinhard Wetzker and Mervyn Singer and Michael Trauner and Michael W. Bauer},
  booktitle={PLoS medicine},
  year={2012}
}
BACKGROUND Hepatic dysfunction and jaundice are traditionally viewed as late features of sepsis and portend poor outcomes. We hypothesized that changes in liver function occur early in the onset of sepsis, yet pass undetected by standard laboratory tests. METHODS AND FINDINGS In a long-term rat model of faecal peritonitis, biotransformation and hepatobiliary transport were impaired, depending on subsequent disease severity, as early as 6 h after peritoneal contamination. Phosphatidylinositol… CONTINUE READING
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Crisp and soft multivariate methods visualize individual cell nuclei in Raman images of liver tissue

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Crisp and soft multivariate methods visualize individual cell nuclei in Raman images of liver tissue sections

  • C Krafft, MA Diderhoshan, P Recknagel, M Miljkovic, M Bauer
  • Vib Spectrosc
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