Liver Carcinogencsis by Methyl Carbamate in F344 Rats and Not in B6C3F1 Mice

@inproceedings{Chan1992LiverCB,
  title={Liver Carcinogencsis by Methyl Carbamate in F344 Rats and Not in B6C3F1 Mice},
  author={Po C. Chan and James Huff and Joseph K. Haseman and John A. Quest and William Carleton Hall},
  booktitle={Japanese journal of cancer research : Gann},
  year={1992}
}
Short-term and long-term carcinogenicity of methyl carbamate (MCB) was evaluated in F344 rats and B6C3F1 mice. In experiments lasting 6, 12, and 18 months, MCB was given in water by gavage to groups of 10 male and 10 female rats at 0 or 400 mg/kg body weight, 5 days per week, and to similar groups of mice at 0 or 1,000 mg/kg. At 6 months, MCB induced atypical mitoses, cytologic alterations, cytomegaly, pigmentation, necrosis, and neoplastic nodules of the liver in rats. At 12 and 18 months… CONTINUE READING