Liver‐targeted antiviral nucleosides: Enhanced antiviral activity of phosphatidyl‐dideoxyguanosine versus dideoxyguanosine in woodchuck hepatitis virus infection in vivo

@article{Korba1996LivertargetedAN,
  title={Liver‐targeted antiviral nucleosides: Enhanced antiviral activity of phosphatidyl‐dideoxyguanosine versus dideoxyguanosine in woodchuck hepatitis virus infection in vivo},
  author={Brent Korba and H Xie and Kristine N Wright and William E. Hornbuckle and John L. Gerin and Bud C. Tennant and Karl Y. Hostetler},
  journal={Hepatology},
  year={1996},
  volume={23}
}
It would be desirable to develop antiviral agents that can be targeted to liver to enhance their antiviral effects and reduce nonhepatic toxicity. 2′,3′‐Dideoxyguanosine (ddG) has been found to be a potent and selective antihepatitis B agent both in vitro and in vivo. To evaluate ddG and its liver‐targeted analog, we synthesized a series of phosphatidyl‐ddGs and incubated them with 2.2.15 cells, which chronically produce hepatitis B virus. 1,2‐Dipalmitoylphosphatidyl‐ dideoxyguanosine (DPP‐ddG… Expand
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