Live recombinant vaccinia virus protects chimpanzees against hepatitis B

@article{Moss1984LiveRV,
  title={Live recombinant vaccinia virus protects chimpanzees against hepatitis B},
  author={Bernard Moss and Geoffrey L. Smith and John L. Gerin and Robert H. Purcell},
  journal={Nature},
  year={1984},
  volume={311},
  pages={67-69}
}
Hepatitis B virus (HBV) is an important human pathogen responsible for over 200 million cases of chronic infection, many of which progress to hepatocellular carcinoma. Although HBV cannot be propagated in tissue culture, highly effective subunit vaccines obtained from the plasma of chronically infected patients have been developed and licensed1–3. Such vaccines are safe but their expense and limited quantities make them unavailable to most Third World countries. Other approaches to vaccine… Expand
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  • Proceedings of the National Academy of Sciences of the United States of America
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