Live oral Salmonella vaccines: potential use of attenuated strains as carriers of heterologous antigens to the immune system.

@article{Dougan1987LiveOS,
  title={Live oral Salmonella vaccines: potential use of attenuated strains as carriers of heterologous antigens to the immune system.},
  author={G. Dougan and Carlos E Hormaeche and Duncan J Maskell},
  journal={Parasite immunology},
  year={1987},
  volume={9 2},
  pages={151-60}
}
Live attenuated strains of salmonellae are showing promise as live oral vaccines against human typhoid fever and other Salmonella infections of man and animals. Attenuation can be achieved by introducing genetically defined, non-reverting mutations into specific genes on the Salmonella chromosome. Mutations in the gal E or aroA genes of Salmonella inhibit the ability of the bacteria to grow in vivo, and strains carrying such lesions are effective vaccines against salmonellosis. Genetic… CONTINUE READING