Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure.

@article{Dukes2016LiveIO,
  title={Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure.},
  author={April A Dukes and Qing Bai and Victor S Van Laar and Yangzhong Zhou and Vladimir Ilin and Christopher N. David and Zeynep S Agim and Joshua L Bonkowsky and Jason R. Cannon and Simon C. Watkins and Claudette M. St. Croix and Edward A Burton and Sarah B Berman},
  journal={Neurobiology of disease},
  year={2016},
  volume={95},
  pages={238-49}
}
Extensive convergent evidence collectively suggests that mitochondrial dysfunction is central to the pathogenesis of Parkinson's disease (PD). Recently, changes in the dynamic properties of mitochondria have been increasingly implicated as a key proximate mechanism underlying neurodegeneration. However, studies have been limited by the lack of a model in which mitochondria can be imaged directly and dynamically in dopaminergic neurons of the intact vertebrate CNS. We generated transgenic… CONTINUE READING