Live four-dimensional optical coherence tomography reveals embryonic cardiac phenotype in mouse mutant.

@article{Lopez2015LiveFO,
  title={Live four-dimensional optical coherence tomography reveals embryonic cardiac phenotype in mouse mutant.},
  author={Andrew L. Lopez and Shang Wang and Kirill V. Larin and Paul Overbeek and Irina V. Larina},
  journal={Journal of biomedical optics},
  year={2015},
  volume={20 9},
  pages={
          090501
        }
}
  • Andrew L. Lopez, Shang Wang, +2 authors Irina V. Larina
  • Published in Journal of biomedical optics 2015
  • Medicine
  • Efficient phenotyping of developmental defects in model organisms is critical for understanding the genetic specification of normal development and congenital abnormalities in humans. We previously reported that optical coherence tomography (OCT) combined with live embryo culture is a valuable tool for mouse embryo imaging and four-dimensional (4-D) cardiodynamic analysis; however, its capability for analysis of mouse mutants with cardiac phenotypes has not been previously explored. Here, we… CONTINUE READING

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