Live cell imaging reveals that the inhibitory FcgammaRIIB destabilizes B cell receptor membrane-lipid interactions and blocks immune synapse formation.

@article{Sohn2008LiveCI,
  title={Live cell imaging reveals that the inhibitory FcgammaRIIB destabilizes B cell receptor membrane-lipid interactions and blocks immune synapse formation.},
  author={Hae Won Sohn and Susan K Pierce and Shiang-Jong Tzeng},
  journal={Journal of immunology},
  year={2008},
  volume={180 2},
  pages={793-9}
}
The FcgammaRIIB is a potent regulator of BCR signaling and as such plays a decisive role in controlling autoimmunity. The use of advanced imaging technologies has provided evidence that the earliest events in Ag-induced BCR signaling include the clustering of the BCR, the selective and transient association of the clustered BCR with raft lipids, and the concentration of BCR clusters in an immune synapse. That lipid rafts play a role in FcgammaRIIB's regulation of BCR signaling was suggested by… CONTINUE READING
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