Live cell imaging of the cancer-related transcription factor RUNX2 during mitotic progression.

@article{Pockwinse2011LiveCI,
  title={Live cell imaging of the cancer-related transcription factor RUNX2 during mitotic progression.},
  author={Shirwin M Pockwinse and Krishna P. Kota and Alexandre Jos{\'e} Christino Quaresma and Anthony N. Imbalzano and Jane B Lian and Andre J van Wijnen and Janet L Stein and Gary S Stein and Jeffrey A. Nickerson},
  journal={Journal of cellular physiology},
  year={2011},
  volume={226 5},
  pages={1383-9}
}
The nuclear matrix bound transcription factor RUNX2 is a lineage-specific developmental regulator that is linked to cancer. We have previously shown that RUNX2 controls transcription of both RNA polymerase II genes and RNA polymerase I-dependent ribosomal RNA genes. RUNX2 is epigenetically retained through mitosis on both classes of target genes in condensed chromosomes. We have used fluorescence recovery after photobleaching to measure the relative binding kinetics of enhanced green… CONTINUE READING
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