Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation.

@article{CavalloMedved2009LivecellID,
  title={Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation.},
  author={Dora Cavallo-Medved and Deborah L Rudy and Galia Blum and Matthew S Bogyo and Dejan Cagli{\vc} and Bonnie F Sloane},
  journal={Experimental cell research},
  year={2009},
  volume={315 7},
  pages={1234-46}
}
Localization of proteases to the surface of endothelial cells and remodeling of the extracellular matrix (ECM) are essential to endothelial cell tube formation and angiogenesis. Here, we partially localized active cathepsin B and its cell surface binding partners, S100A/p11 (p11) of the annexin II heterotetramer (AIIt), to caveolae of human umbilical vein endothelial cells (HUVEC). Via a live-cell proteolysis assay, we observed that degradation products of quenched-fluorescent (DQ)-proteins (i… CONTINUE READING
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