Live attenuated pseudorabies virus expressing envelope glycoprotein E1 of hog cholera virus protects swine against both pseudorabies and hog cholera.

@article{Zijl1991LiveAP,
  title={Live attenuated pseudorabies virus expressing envelope glycoprotein E1 of hog cholera virus protects swine against both pseudorabies and hog cholera.},
  author={M van Zijl and Gert Wensvoort and E P de Kluyver and Michele Hulst and Hanneke van der Gulden and Arnold Leonard Jozef Gielkens and Anton Berns and Rob J. M. Moormann},
  journal={Journal of virology},
  year={1991},
  volume={65 5},
  pages={
          2761-5
        }
}
To investigate whether live attenuated pseudorabies virus (PRV) can be used as a vaccine vector, PRV recombinants that expressed envelope glycoprotein E1 of hog cholera virus (HCV) were generated. Pigs inoculated with these recombinants developed high levels of neutralizing antibodies against PRV and HCV and were protected against both pseudorabies and hog cholera (classical swine fever). 

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