Live attenuated influenza vaccine provides superior protection from heterologous infection in pigs with maternal antibodies without inducing vaccine-associated enhanced respiratory disease.

@article{Vincent2012LiveAI,
  title={Live attenuated influenza vaccine provides superior protection from heterologous infection in pigs with maternal antibodies without inducing vaccine-associated enhanced respiratory disease.},
  author={Amy L. Vincent and Wenjun Ma and Kelly Milton Lager and Juergen A. Richt and Bruce H. Janke and Matthew Robert Sandbulte and Philip C Gauger and Crystal L Loving and Richard R. J. Webby and Adolfo Garc{\'i}a-Sastre},
  journal={Journal of virology},
  year={2012},
  volume={86 19},
  pages={
          10597-605
        }
}
Control of swine influenza A virus (IAV) in the United States is hindered because inactivated vaccines do not provide robust cross-protection against the multiple antigenic variants cocirculating in the field. Vaccine efficacy can be limited further for vaccines administered to young pigs that possess maternally derived immunity. We previously demonstrated that a recombinant A/sw/Texas/4199-2/1998 (TX98) (H3N2) virus expressing a truncated NS1 protein is attenuated in swine and has potential… CONTINUE READING

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