Live attenuated Shigella dysenteriae type 1 vaccine strains overexpressing shiga toxin B subunit.

@article{Wu2011LiveAS,
  title={Live attenuated Shigella dysenteriae type 1 vaccine strains overexpressing shiga toxin B subunit.},
  author={Tao Wu and Christen L Grassel and Myron M. Levine and Eileen M. Barry},
  journal={Infection and immunity},
  year={2011},
  volume={79 12},
  pages={4912-22}
}
Shigella dysenteriae serotype 1 (S. dysenteriae 1) is unique among the Shigella species and serotypes in the expression of Shiga toxin which contributes to more severe disease sequelae and the ability to cause explosive outbreaks and pandemics. S. dysenteriae 1 shares characteristics with other Shigella species, including the capability of causing clinical illness with a very low inoculum (10 to 100 CFU) and resistance to multiple antibiotics, underscoring the need for efficacious vaccines and… CONTINUE READING

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