Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children.

@article{Hoft2011LiveAI,
  title={Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children.},
  author={Daniel F. Hoft and Elizabeth Babusis and S. G. Worku and Charles T. Spencer and Kathleen R. Lottenbach and Steven M. Truscott and Getahun Abate and Isaac G. Sakala and Kathryn Margaret Edwards and Clarence Buddy Creech and Michael A. Gerber and David I. Bernstein and Frances Newman and Irene Graham and Edwin L. Anderson and Robert B. Belshe},
  journal={The Journal of infectious diseases},
  year={2011},
  volume={204 6},
  pages={845-53}
}
BACKGROUND Two doses of either trivalent live attenuated or inactivated influenza vaccines (LAIV and TIV, respectively) are approved for young children (≥ 24 months old for LAIV and ≥ 6 months old for TIV) and induce protective antibody responses. However, whether combinations of LAIV and TIV are safe and equally immunogenic is unknown. Furthermore, LAIV is more protective than TIV in children for unclear reasons. METHODS Children 6-35 months old were administered, 1 month apart, 2 doses of… CONTINUE READING
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Flow-cytometric detection of vaccinia-induced memory effector CD41, CD81, and cd TCR1 T cells capable of antigen-specific expansion and effector functions

  • G Abate, J Eslick, FK Newman
  • J Infect Dis
  • 2005
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