Live Recombinant Salmonella Typhi Vaccines Constructed to Investigate the Role of rpoS in Eliciting Immunity to a Heterologous Antigen

@inproceedings{Shi2010LiveRS,
  title={Live Recombinant Salmonella Typhi Vaccines Constructed to Investigate the Role of rpoS in Eliciting Immunity to a Heterologous Antigen},
  author={Huoying Shi and Javier Santander and Karen E. Brenneman and Soo-Young Wanda and Shifeng Wang and Patti Senechal and Wei Sun and Kenneth L. Roland and Roy Curtiss},
  booktitle={PloS one},
  year={2010}
}
We hypothesized that the immunogenicity of live Salmonella enterica serovar Typhi vaccines expressing heterologous antigens depends, at least in part, on its rpoS status. As part of our project to develop a recombinant attenuated S. Typhi vaccine (RASTyV) to prevent pneumococcal diseases in infants and children, we constructed three RASTyV strains… CONTINUE READING