Live Imaging of Xwnt5A-ROR2 Complexes

  title={Live Imaging of Xwnt5A-ROR2 Complexes},
  author={Veronika Wallkamm and Ren{\'e} M. D{\"o}rlich and Karolin Rahm and Tina Klessing and Gerd Ulrich Nienhaus and Doris Wedlich and Dietmar Gradl and Shao-Jun Tang},
  booktitle={PloS one},
Secreted molecules of the Wnt family regulate key decisions in embryogenesis and adult tissue homeostasis by activating a complex network of Wnt signaling pathways. Although the different branches of Wnt signaling have been studied for more than 25 years, fluorophore tagged constructs for live cell imaging of Wnt molecules activating the Wnt/β-catenin pathway have become available only recently. We have generated a fluorophore tagged Wnt construct of the Xenopus Wnt5a protein (Xwnt5A) with the… CONTINUE READING