Live Attenuated Influenza Vaccines by Computer-Aided Rational Design

  title={Live Attenuated Influenza Vaccines by Computer-Aided Rational Design},
  author={Steffen Mueller and J Robert Coleman and Dimitris Papamichail and Charles B. Ward and Anjaruwee S. Nimnual and Bruce Futcher and Steven Skiena and Eckard J Wimmer},
  booktitle={Nature Biotechnology},
Despite existing vaccines and enormous efforts in biomedical research, influenza annually claims 250,000–500,000 lives worldwide, motivating the search for new, more effective vaccines that can be rapidly designed and easily produced. We applied the previously described synthetic attenuated virus engineering (SAVE) approach to influenza virus strain A/PR/8/34 to rationally design live attenuated influenza virus vaccine candidates through genome-scale changes in codon-pair bias. As attenuation… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
92 Citations
24 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 92 extracted citations


Publications referenced by this paper.
Showing 1-10 of 24 references

Field's Virology. Knipe, DM

  • P. Palese, ML. Shaw
  • (LWW); Philadelphia:
  • 2007

Similar Papers

Loading similar papers…