Litter size, age-related memory impairments, and microglial changes in rat dentate gyrus: stereological analysis and three dimensional morphometry.

@article{Viana2013LitterSA,
  title={Litter size, age-related memory impairments, and microglial changes in rat dentate gyrus: stereological analysis and three dimensional morphometry.},
  author={Lane Coelho Viana and Cristiani Maria de Lima and M{\'a}rcio A. Oliveira and Rog{\'e}rio Borges and Teresa Cardoso and Izabela Negr{\~a}o Frota de Almeida and Daniel Guerreiro Diniz and Jo{\~a}o Bento-Torres and Ant{\^o}nio M{\'a}rcio de Safim Arantes Pereira and Manuella Batista-de-Oliveira and Andr{\'e}ia Albuquerque Cunha Lopes and Rui Fernando Marques Silva and Ricardo Abadie-Guedes and A Am{\^a}ncio Dos Santos and Denise Sandrelly Cavalcanti de Lima and Pedro Fernando da Costa Vasconcelos and Colm Cunningham and Rubem Carlos Ara{\'u}jo Guedes and Cristovam Wanderley Picanço-Diniz},
  journal={Neuroscience},
  year={2013},
  volume={238},
  pages={280-96}
}
It has been demonstrated that rat litter size affects the immune cell response, but it is not known whether the long-term effects aggravate age-related memory impairments or microglial-associated changes. To that end, we raised sedentary Wistar rats that were first suckled in small or large litters (6 or 12pups/dam, respectively), then separated into groups of 2-3 rats from the 21st post-natal day to study end. At 4months (young adult) or 23months (aged), all individual rats were submitted to… CONTINUE READING