Litopenaeus vannamei Toll-interacting protein (LvTollip) is a potential negative regulator of the shrimp Toll pathway involved in the regulation of the shrimp antimicrobial peptide gene penaeidin-4 (PEN4).

@article{Wang2013LitopenaeusVT,
  title={Litopenaeus vannamei Toll-interacting protein (LvTollip) is a potential negative regulator of the shrimp Toll pathway involved in the regulation of the shrimp antimicrobial peptide gene penaeidin-4 (PEN4).},
  author={Pei-Hui Wang and Zhi-Hua Gu and Ding-Hui Wan and Wei-bin Zhu and Wei Qiu and Yong-gui Chen and Shao-Ping Weng and X Yu and Jian-guo He},
  journal={Developmental and comparative immunology},
  year={2013},
  volume={40 3-4},
  pages={266-77}
}
The Toll-like receptor (TLR)-nuclear factor (NF)-κB signaling pathway is evolutionarily conserved from insects to mammals as a regulator of the expression of immune-related genes. In mammals, TLR-NF-κB signaling is tightly controlled because excessive activation of this pathway can result in severe damage to the host. The mammalian Toll-interacting protein (Tollip) has an important function in the negative regulation of this pathway, but no reports about invertebrate Tollip have been published… CONTINUE READING
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