Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.

Abstract

The proteins MDM2 and MDM4 are key negative regulators of the tumor suppressor protein p53, which are frequently upregulated in cancer cells. They inhibit the transactivation activity of p53 by binding separately or in concert to its transactivation domain. MDM2 is also a ubiquitin ligase that leads to the degradation of p53. Accordingly, MDM2 and MDM4 are… (More)
DOI: 10.1073/pnas.1215060109

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