Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia.

@article{Ishizawa2008LithocholicAD,
  title={Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia.},
  author={Michiyasu Ishizawa and Manabu Matsunawa and Ryutaro Adachi and Shigeyuki Uno and Kazumasa Ikeda and Hiroyuki Masuno and Masato Shimizu and Ken-ichi Iwasaki and Sachiko Yamada and Makoto Makishima},
  journal={Journal of lipid research},
  year={2008},
  volume={49 4},
  pages={763-72}
}
1alpha,25-Dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], a vitamin D receptor (VDR) ligand, regulates calcium homeostasis and also exhibits noncalcemic actions on immunity and cell differentiation. In addition to disorders of bone and calcium metabolism, VDR ligands are potential therapeutic agents in the treatment of immune disorders, microbial infections, and malignancies. Hypercalcemia, the major adverse effect of vitamin D(3) derivatives, limits their clinical application. The secondary bile acid… CONTINUE READING
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