Lithium treatment reduces suicide risk in recurrent major depressive disorder.

@article{Guzzetta2007LithiumTR,
  title={Lithium treatment reduces suicide risk in recurrent major depressive disorder.},
  author={Francesca Guzzetta and L. Tondo and F. Centorrino and R. Baldessarini},
  journal={The Journal of clinical psychiatry},
  year={2007},
  volume={68 3},
  pages={
          380-3
        }
}
OBJECTIVE Evidence that clinical treatment reduces suicide risk in major depressive disorder (MDD) is limited and inconsistent. Since lithium shows major antisuicidal effects in bipolar disorders and in heterogeneous mood disorder samples, we evaluated evidence of antisuicidal effects of lithium in patients with recurrent MDD. DATA SOURCES We searched MEDLINE (January 1966 to April 2006; search terms: lithium, suicide, affective disorder, depression, major depression, and mood disorder) for… Expand
Pharmacological prevention of suicide in patients with major mood disorders
The risk of self-destructive behavior in mood disorders is an inherent phenomenon and suicidal behavior in patients with unipolar or bipolar major mood disorders strongly relates to the presence andExpand
Antisuicidal Effects in Mood Disorders: Are They Unique to Lithium?
TLDR
Substantial reduction of risks of suicide and attempts with long-term lithium treatment, particularly in depressive phases of BD and in MDD, and in mixed (agitated-dysphoric) states than in manic or hypomanic periods. Expand
Long-term lithium treatment in the prevention of suicidal behavior in bipolar disorder patients
TLDR
Data from meta-analyses consistently indicate marked reductions of suicidal behavior and mortality during long-term treatment with lithium salts in bipolar disorder patients, and possibly also in unipolar, recurrent major depressive, perhaps even more effectively than with anticonvulsants proposed as mood-stabilizers. Expand
Suicide in psychiatric disorders: rates, risk factors, and therapeutics
TLDR
Lithium is underutilized clinically but has substantial evidence of long-term preventive effects on attempts and suicide in bipolar disorder (BD), and possibly also in patients with major depressive disorder (MDD) and some second-generation antipsychotics have evidence of efficacy in depression, particularly acute bipolar depression. Expand
Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis
TLDR
Lithium is an effective treatment for reducing the risk of suicide in people with mood disorders and may exert its antisuicidal effects by reducing relapse of mood disorder. Expand
Depression , suicide , and violence Suicide and depression
Introduction Suicide is a complex and multicausal phenomenon. It has a strong association with mental disorders, particularly major depressive disorder. Suicidal behaviors (both fatal and non-fatal)Expand
Suicide Prevention with Lithium
TLDR
The risk of completed suicide is considerable and about 20 times higher in patients with mood disorders than in the general population, and estimates are around 10–20 %. Expand
The Effect of Pharmacotherapy on Suicide Rates in Bipolar Patients
TLDR
Several clinical trials provide evidence that effective acute and long‐term treatment of bipolar depression provides a strong protection against suicide, suicide attempts, and probably against other complications of this disorder. Expand
Lithium treatment for unipolar major depressive disorder: Systematic review
TLDR
The findings indicate efficacy of lithium as a treatment for some aspects of major depressive disorder, especially as an add-on to antidepressants and for long-term prophylaxis. Expand
Suicidal Behavior in Mood Disorders: Response to Pharmacological Treatment
TLDR
In bipolar disorder, an underprescribed medical intervention with substantial evidence of preventive effects on suicidal behavior is long-term treatment with lithium, but it is unclear whether this effect is specifically antisuicidal or reflects beneficial effects of lithium on depression, mood instability, and perhaps aggression and impulsivity. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 41 REFERENCES
Lithium treatment and risk of suicidal behavior in bipolar disorder patients.
TLDR
Suicidal behavior was strongly associated with prior suicide attempts, more time depressed, and younger age or recent onset and lithium maintenance was associated with marked reduction of life-threatening suicidal acts, the number of which sharply increased after discontinuing lithium. Expand
Suicide mortality in patients on lithium maintenance therapy.
TLDR
It is concluded that maintenance treatment of mood disorders reduces the suicide rate in this vulnerable group of patients. Expand
Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review.
TLDR
Risks of completed and attempted suicide were consistently lower, by approximately 80%, during treatment of bipolar and other major affective disorder patients with lithium for an average of 18 months, and these benefits were sustained in randomized as well as open clinical trials. Expand
Suicide risk in bipolar disorder during treatment with lithium and divalproex.
TLDR
Among patients treated for bipolar disorder, risk of suicide attempt and suicide death is lower during treatment with lithium than duringreatment with divalproex, according to a retrospective cohort study conducted at 2 large integrated health plans in California and Washington. Expand
Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT).
TLDR
It is suggested that clozapine therapy significantly reduces suicidal behavior in patients with schizophrenia and schizoaffective disorder at high risk for suicide, and use of clozAPine in this population should lead to a significant reduction in suicidal behavior. Expand
Suicidality in pediatric patients treated with antidepressant drugs.
TLDR
Use of antidepressant drugs in pediatric patients is associated with a modestly increased risk of suicidality, and a meta-analysis was conducted to obtain overall suicidity risk estimates. Expand
Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials.
TLDR
Lithium is effective in the prevention of suicide, deliberate self-harm, and death from all causes in patients with mood disorders, according to the Cochrane Collaboration. Expand
Suicide in 406 Mood-Disorder Patients With and Without Long-Term Medication: A 40 to 44 Years' Follow-Up
ABSTRACT There is no data on the variation in the suicide risk over lifetime and on the suicide-preventive effect of the long-term treatment of mood-disorder patients with antidepressants andExpand
Effectiveness and outcome predictors of long-term lithium prophylaxis in unipolar major depressive disorder.
TLDR
The results of this long-term naturalistic study, with its long observation period and the inclusion of comedication as a confounding variable, indicate that lithium is a potent prophylactic agent for unipolar MDD in a naturalistic setting. Expand
The Antisuicidal and Mortality-Reducing Effect of Lithium Prophylaxis: Consequences for Guidelines in Clinical Psychiatry
The suicide-related mortality among patients with affective disorders is approximately 30 times higher, and overall mortality 2 to 3 times higher, than suicide-related mortality in the generalExpand
...
1
2
3
4
5
...