Lithium treatment causes gliosis and modifies the morphology of hippocampal astrocytes in rats.

Abstract

The biological basis of the clinical efficacy of lithium in the treatment of mental illness has been extensively studied in neurones, but little is known about the effects of the drug on glia. Recently we showed that treatment of rats with clinically relevant doses of lithium chloride results in a 35% increase in the immunocontent of the astrocyte marker… (More)

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