Lithium treatment and prophylaxis in unipolar depression: a meta-analysis.

  title={Lithium treatment and prophylaxis in unipolar depression: a meta-analysis.},
  author={F G Souza and Guy M. Goodwin},
  journal={The British journal of psychiatry : the journal of mental science},
Meta-analysis was used to establish the efficacy of lithium in acute treatment and prophylaxis of depressive illness from existing published clinical trials. Effect sizes were measured by the odds ratio using the Mantel-Haenszel method and the Pearson product-moment correlation coefficient. Some benefit from lithium, compared with other treatments, emerged from trials of acute treatment. Lithium was clearly superior to placebo in the acute treatment of bipolar depressed patients. In controlled… CONTINUE READING

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