Lithium stimulates gene expression through the AP-1 transcription factor pathway.

@article{Yuan1998LithiumSG,
  title={Lithium stimulates gene expression through the AP-1 transcription factor pathway.},
  author={Pei Xiang Yuan and Guang Chen and Linong Huang and Husseini K. Manji},
  journal={Brain research. Molecular brain research},
  year={1998},
  volume={58 1-2},
  pages={225-30}
}
Lithium, a monovalent cation, is the mainstay in the treatment of manic-depressive (MDI) illness, but despite extensive research, its mechanism of action remains to be elucidated. Since lithium requires chronic administration for therapeutic efficacy, and because its beneficial effects last well beyond its discontinuation, it has been postulated that lithium may exert major effects at the genomic level. In the present study we found that lithium, at therapeutically relevant concentrations… CONTINUE READING

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