Lithium stabilizes the polarized lens epithelial phenotype and inhibits proliferation, migration, and epithelial mesenchymal transition.

@article{Stump2006LithiumST,
  title={Lithium stabilizes the polarized lens epithelial phenotype and inhibits proliferation, migration, and epithelial mesenchymal transition.},
  author={Richard J W Stump and Frank J. Lovicu and Sharyn L Ang and Sanjay K Pandey and John W. McAvoy},
  journal={The Journal of pathology},
  year={2006},
  volume={210 2},
  pages={249-57}
}
Posterior capsule opacification (PCO) is a common complication of cataract surgery caused by epithelial mesenchymal transition (EMT) and aberrant lens cell growth. One path to prevention depends on maintaining the quiescent lens epithelial phenotype. Here we report that lithium chloride (LiCl) is a potent stabilizer of the lens epithelial phenotype. In lens epithelial explants (controls), at low cell density, cells readily depolarized, spread out, and proliferated. By contrast, in the presence… CONTINUE READING

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