Lithium rescues synaptic plasticity and memory in Down syndrome mice.

@article{Contestabile2013LithiumRS,
  title={Lithium rescues synaptic plasticity and memory in Down syndrome mice.},
  author={Antonio Contestabile and Barbara Greco and Diego Ghezzi and Valter Tucci and Fabio Benfenati and Laura Gasparini},
  journal={The Journal of clinical investigation},
  year={2013},
  volume={123 1},
  pages={
          348-61
        }
}
Down syndrome (DS) patients exhibit abnormalities of hippocampal-dependent explicit memory, a feature that is replicated in relevant mouse models of the disease. Adult hippocampal neurogenesis, which is impaired in DS and other neuropsychiatric diseases, plays a key role in hippocampal circuit plasticity and has been implicated in learning and memory. However, it remains unknown whether increasing adult neurogenesis improves hippocampal plasticity and behavioral performance in the… 

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