Lithium regulates protein tyrosine phosphatase activity in vitro and in vivo

@article{Zhen2002LithiumRP,
  title={Lithium regulates protein tyrosine phosphatase activity in vitro and in vivo},
  author={Xuechu Zhen and Claudio Torres and Eitan Friedman},
  journal={Psychopharmacology},
  year={2002},
  volume={162},
  pages={379-384}
}
Rationale. Lithium has been shown to regulate multiple intracellular signaling pathways by affecting various protein kinases. However, the counterpart of protein kinases, i.e., protein phosphatases may play an important role in lithium-regulated cellular signaling and functions. Objectives. The present work was designed to test the effect of lithium on protein phosphatases in vitro and in vivo. Methods. PC12 cells were used as an in vitro model to characterize the effect of lithium on protein… CONTINUE READING