Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease

  title={Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease},
  author={Camila Teixeira Mendes and F{\'a}bio Borges Mury and Elo{\'i}sa de S{\'a} Moreira and Fernando Lopes Alberto and Orestes Vicente Forlenza and Emmanuel Dias-Neto and Wagner F. Gattaz},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
There is evidence of increased systemic expression of active GSK3B in Alzheimer’s disease patients, which apparently is associated with the formation of senile plaques and neurofibrillary tangles. Due to its central role in the pathogenesis of AD, GSK3B is currently a promising target of the pharmaceutical industry. Whilst trials with specific GSK inhibitors in AD are under way, major attention has been focused on the neuroprotective effects of lithium. Whereas the direct and indirect… CONTINUE READING
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