Lithium protects ethanol-induced neuronal apoptosis.

  title={Lithium protects ethanol-induced neuronal apoptosis.},
  author={Jin Zhong and Xianlin Yang and Weiguo Yao and Weihua Lee},
  journal={Biochemical and biophysical research communications},
  volume={350 4},
Lithium is widely used for the treatment of bipolar disorder. Recent studies have demonstrated its neuroprotective effect. Ethanol is a potent neurotoxin that is particularly harmful to the developing nervous system. In this study, we evaluated lithium's neuroprotection against ethanol-induced apoptosis. Transient exposure of infant mice to ethanol caused apoptotic cell death in brain, which was prevented significantly by administering a low dose of lithium 15min later. In cultured cerebellar… CONTINUE READING


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