Lithium prevents excitotoxic cell death of motoneurons in organotypic slice cultures of spinal cord.

@article{Calder2010LithiumPE,
  title={Lithium prevents excitotoxic cell death of motoneurons in organotypic slice cultures of spinal cord.},
  author={Jordi Calder{\'o} and N{\'u}ria Molist Brunet and Olga Tarabal and L{\'i}dia Piedrafita and Marta Hereu and Vict{\`o}ria Ayala and Josep E. Esquerda},
  journal={Neuroscience},
  year={2010},
  volume={165 4},
  pages={1353-69}
}
Several studies have reported the neuroprotective effects of lithium (Li) suggesting its potential in the treatment of neurological disorders, among of them amyotrophic lateral sclerosis (ALS). Although the cause of motoneuron (MN) death in ALS remains unknown, there is evidence that glutamate-mediated excitotoxicity plays an important role. In the present study we used an organotypic culture system of chick embryo spinal cord to explore the presumptive neuroprotective effects of Li against… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…