Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial.

@article{Geddes2010LithiumPV,
  title={Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial.},
  author={John R. Geddes and Guy M. Goodwin and Jennifer Rendell and Jean Michel Azorin and Andrea Cipriani and Michael J Ostacher and Richard Morriss and Nicola C. Alder and Ed Juszczak},
  journal={Lancet},
  year={2010},
  volume={375 9712},
  pages={385-95}
}
BACKGROUND Lithium carbonate and valproate semisodium are both recommended as monotherapy for prevention of relapse in bipolar disorder, but are not individually fully effective in many patients. If combination therapy with both agents is better than monotherapy, many relapses and consequent disability could be avoided. We aimed to establish whether lithium plus valproate was better than monotherapy with either drug alone for relapse prevention in bipolar I disorder. METHODS 330 patients aged… CONTINUE READING