Lithium pharmacokinetics during cisplatin-based chemotherapy: a case report

  title={Lithium pharmacokinetics during cisplatin-based chemotherapy: a case report},
  author={Jos H. Beijnen and Evert Bais and Wim W. ten Bokkel Huinink},
  journal={Cancer Chemotherapy and Pharmacology},
A 33-year-old patient, treated for several years with lithium carbonate for a manic depressive disorder, received four courses of combination chemotherapy (bleomycin, etoposide, cisplatin) after the diagnosis of disseminated testicular cancer. Lithium therapy was continued throughout all the courses. Serum and urine lithium concentrations were determined during and between all chemotherapy courses. During the first course a transient 64% decrease in serum lithium concentrations was found. This… CONTINUE READING
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