Lithium orotate: A superior option for lithium therapy?

@article{Pacholko2021LithiumOA,
  title={Lithium orotate: A superior option for lithium therapy?},
  author={Anthony G. Pacholko and Lane K. Bekar},
  journal={Brain and Behavior},
  year={2021},
  volume={11}
}
Bipolar disorder (BD) poses a significant public health concern, with roughly one‐quarter of sufferers attempting suicide. BD is characterized by manic and depressive mood cycles, the recurrence of which can be effectively curtailed through lithium therapy. Unfortunately, the most frequently employed lithium salt, lithium carbonate (Li2CO3), is associated with a host of adverse health outcomes following chronic use: these unwanted effects range from relatively minor inconveniences (e.g… 

References

SHOWING 1-10 OF 186 REFERENCES
Lithium side effects and toxicity: prevalence and management strategies
  • M. Gitlin
  • Medicine
    International Journal of Bipolar Disorders
  • 2016
TLDR
A simple set of management strategies that involve the timing of the lithium dose, minimizing lithium levels within the therapeutic range and, in some situations, the prescription of side effect antidotes will minimize the side effect burden for patients.
Is the safety of lithium no longer in the balance?
An Oldie but Goodie: Lithium in the Treatment of Bipolar Disorder through Neuroprotective and Neurotrophic Mechanisms
TLDR
This review has overviewed the clinical aspects of lithium use for BD, and has focused on the neuroprotective and neurotrophic effects of lithium.
The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis.
TLDR
The evidence reviewed here suggests that lithium's neurotrophic effects in BD are an example of an old molecule acting as a new proof-of-concept agent, which will likely lead to the development of not only improved therapeutics for BD, but to neurotrophic enhancers that could prove useful in the treatment of many other illnesses.
Reasons for lithium discontinuation in men and women with bipolar disorder: a retrospective cohort study
TLDR
Stopping lithium treatment is common and occurs mostly due to adverse effects, so it is important to discuss potential adverse effects with patients before initiation and continuously during lithium treatment, to reduce the frequency of potentially unnecessary discontinuations.
Clinical Pharmacokinetics of Lithium
TLDR
Although lithium has been used in a variety of psychiatric and medical illnesses, its FDA approved indications include the acute treatment of mania and maintenance treatment of bipolar disorder.
Medication nonadherence in bipolar disorder: a narrative review
TLDR
Clinicians should routinely enquire about nonadherence in a nonjudgmental fashion and potential steps to improve adherence include simple pragmatic strategies related to prescribing including shared decision-making, psychoeducation with a clear focus on adherence and managing comorbid substance misuse and improving therapeutic alliance.
Spectrum of lithium induced thyroid abnormalities: a current perspective
TLDR
More frequent assessment of thyroid function status and size during the course of therapy is recommended among middle aged females, patients with a family history of thyroid disease and those positive for thyroid auto-antibodies.
The science and practice of lithium therapy
TLDR
Lithium is a safe and effective agent that should be used first-line for the treatment of bipolar disorder and a better understanding of its science alongside strategic management of its plasma levels will ensure both wider utility and improved outcomes.
Lithium: A classic drug—Frequently discussed, but, sadly, seldom prescribed!
  • O. Zivanović
  • Psychology, Medicine
    The Australian and New Zealand journal of psychiatry
  • 2017
TLDR
Despite abundant evidence regarding the efficacy of lithium and its effectiveness in the treatment of bipolar disorders, its use is declining at the beginning of the 21st century.
...
...