Lithium orotate: A superior option for lithium therapy?

  title={Lithium orotate: A superior option for lithium therapy?},
  author={Anthony G. Pacholko and Lane K. Bekar},
  journal={Brain and Behavior},
Bipolar disorder (BD) poses a significant public health concern, with roughly one‐quarter of sufferers attempting suicide. BD is characterized by manic and depressive mood cycles, the recurrence of which can be effectively curtailed through lithium therapy. Unfortunately, the most frequently employed lithium salt, lithium carbonate (Li2CO3), is associated with a host of adverse health outcomes following chronic use: these unwanted effects range from relatively minor inconveniences (e.g… 


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  • Medicine
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Lithium is a safe and effective agent that should be used first-line for the treatment of bipolar disorder and a better understanding of its science alongside strategic management of its plasma levels will ensure both wider utility and improved outcomes.
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    The Australian and New Zealand journal of psychiatry
  • 2017
Despite abundant evidence regarding the efficacy of lithium and its effectiveness in the treatment of bipolar disorders, its use is declining at the beginning of the 21st century.