Lithium nephrotoxicity revisited
@article{Grnfeld2009LithiumNR, title={Lithium nephrotoxicity revisited}, author={Jean Pierre Gr{\"u}nfeld and Bernard C Rossier}, journal={Nature Reviews Nephrology}, year={2009}, volume={5}, pages={270-276} }
Lithium is widely used to treat bipolar disorder. Nephrogenic diabetes insipidus (NDI) is the most common adverse effect of lithium and occurs in up to 40% of patients. Renal lithium toxicity is characterized by increased water and sodium diuresis, which can result in mild dehydration, hyperchloremic metabolic acidosis and renal tubular acidosis. The concentrating defect and natriuretic effect develop within weeks of lithium initiation. After years of lithium exposure, full-blown nephropathy…
251 Citations
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References
SHOWING 1-10 OF 61 REFERENCES
Lithium-induced nephrogenic diabetes insipidus: renal effects of amiloride.
- MedicineClinical journal of the American Society of Nephrology : CJASN
- 2008
By inference, amiloride-induced reduction of lithium uptake in the principal cells of the collecting duct improves responsiveness to AVP-stimulated translocation of AQP2 to the apical membrane of the principal Cells.
Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria.
- Biology, MedicineAmerican journal of physiology. Renal physiology
- 2005
Findings temporally link decreased GSK-3 activity to enhanced renal COX2 expression andCOX2-derived urine PGE(2) excretion and COX1-/- mice to lithium-associated polyuria, suggesting that COX 2, but not COX 1, plays a critical role in lithium-induced polyuria.
Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity.
- Biology, MedicineJournal of the American Society of Nephrology : JASN
- 2006
The first proper cell model to study lithium-induced NDI was developed and it was demonstrated that the lithium- induced downregulation of AQP2 and development of NDI occur independent of adenylyl cyclase activity in vitro and in vivo.
Lithium-induced nephropathy: Rate of progression and prognostic factors.
- MedicineKidney international
- 2003
Lithium-induced chronic renal disease is slowly progressive and its rate of progression is related to the duration of lithium administration, which represents 0.22% of all causes of ESRD in France.
Lithium nephrotoxicity: a progressive combined glomerular and tubulointerstitial nephropathy.
- MedicineJournal of the American Society of Nephrology : JASN
- 2000
In conclusion, lithium nephrotoxicity primarily targets distal and collecting tubules, with a higher incidence of proteinuria and associated glomerular pathology than recognized previously.
Segment-specific ENaC downregulation in kidney of rats with lithium-induced NDI.
- BiologyAmerican journal of physiology. Renal physiology
- 2003
A marked and highly segment-specific downregulation of beta- ENaC and gamma-ENaC is identified in the cortical and outer medullary collecting duct, chief sites for collecting duct sodium reabsorption, in rats with a lithium-induced increase in fractional excretion of sodium.
Amelioration of polyuria by amiloride in patients receiving long-term lithium therapy.
- MedicineThe New England journal of medicine
- 1985
It is concluded that amiloride mitigates lithium-induced polyuria, at least partly, by blunting the inhibitory effect of lithium on water transport in the renal collecting tubule and obviating the need for potassium supplementation in the treatment of this kind of polyuria.
Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: Mechanisms for aquaporin 2 down-regulation and cellular proliferation
- BiologyProceedings of the National Academy of Sciences
- 2008
This study provides a comprehensive analysis of the proteins affected by lithium treatment in the IMCD and provides clues to potential lithium targets in the brain.
Lithium toxicity: a double-edged sword.
- MedicineKidney international
- 2008
A biopsy diagnosis of chronic active interstitial nephritis likely secondary to lithium toxicity was made and the presence of numerous cortical micro cysts and the focal global and segmental glomerulosclerosis (FSGS) were also attributed to lithium.
Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla.
- Medicine, BiologyThe Journal of clinical investigation
- 1995
Lithium causes marked downregulation of AQP2 expression, only partially reversed by cessation of therapy, thirsting or dDAVP treatment, consistent with clinical observations of slow recovery from lithium-induced urinary concentrating defects.